CONCOMITANT ADMINISTRATION OF PROMETHAZINE PRODUCTS WITH OTHER RESPIRATORY DEPRESSANTS HAS AN ASSOCIATION WITH RESPIRATORY DEPRESSION, AND SOMETIMES DEATH, IN PEDIATRIC PATIENTS. Limit alcoholic beverages. In pediatric patients who are acutely ill associated with dehydration, there is an increased susceptibility to dystonias with the use of promethazine HCl. It is not known whether promethazine or dextromethorphan is excreted in human milk. and untreated or inadequately treated extrapyramidal signs and symptoms (EPS). Drowsiness and confusion can increase the risk of falling. Epinephrine – Because of the potential for promethazine to reverse epinephrine's vasopressor effect, epinephrine should NOT be used to treat hypotension associated with promethazine overdose. Properly discard this product when it is expired or no longer needed. Hematologic – Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis. ½ to 1 teaspoonful (2.5 to 5 mL) every 4 to 6 hours, not to exceed 20 mL in 24 hours. Was this review helpful? Stop using Promethazine with DM and call your doctor at once if you have any of these serious side effects: uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; tremors, twitching, or uncontrolled muscle movements in your face, arms, or legs. Central Nervous System – Drowsiness is the most prominent CNS effect of this drug. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Do not use any other over-the-counter cough, cold, or allergy medication without first asking your doctor or pharmacist. Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system (CNS) pathology. Promethazine hydrochloride and dextromethorphan hydrobromide oral solution is contraindicated for children under 2 years of age (see WARNINGS – Black Box Warning and Use In Pediatric Patients). Inability to sleep due to cough. Specific studies to test the action of the drug on parturition, lactation, and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these parameters. Thus, concomitant administration of promethazine with dextromethorphan and MAO inhibitors should be avoided (see CONTRAINDICATIONS). Drink plenty of fluids while you are using this medication unless otherwise directed by your doctor. Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine. Available for Android and iOS devices. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.

CONCOMITANT ADMINISTRATION OF PROMETHAZINE PRODUCTS WITH OTHER RESPIRATORY DEPRESSANTS HAS AN ASSOCIATION WITH RESPIRATORY DEPRESSION, AND SOMETIMES DEATH, IN PEDIATRIC PATIENTS. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Promethazine DM (FDA) Related treatment guides. Get trusted health information. In pediatric patients who are acutely ill associated with dehydration, there is an increased susceptibility to dystonias with the use of promethazine HCl. Tell your doctor right away if any of these unlikely but serious side effects occur: decreased coordination, difficulty urinating, shaking (tremor).

The big day is coming! This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Promethazine and dextromethorphan may cause marked drowsiness or impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. Going back to doc's to ask for something else!Hide Full Comment. Promethazine hydrochloride, a phenothiazine derivative, is chemically designated as 10H-Phenothiazine-10-ethanamine, N,N, α-trimethyl-monohydrochloride.

Complementary therapies to ease symptoms. Promethazine was nonmutagenic in the Salmonella test system of Ames.

RESPIRATORY DEPRESSION AND APNEA, SOMETIMES ASSOCIATED WITH DEATH, ARE STRONGLY ASSOCIATED WITH PROMETHAZINE PRODUCTS AND ARE NOT DIRECTLY RELATED TO INDIVIDUALIZED WEIGHT-BASED DOSING, WHICH MIGHT OTHERWISE PERMIT SAFE ADMINISTRATION. WebMD does not provide medical advice, diagnosis or treatment. Do not use it later for another condition unless told to do so by your doctor. Search by name or medical condition.

Dextromethorphan is metabolized primarily by liver enzymes undergoing O-demethylation, N-demethylation, and partial conjugation with glucuronic acid and sulfate.

Limited data suggest that use of promethazine HCl during labor and delivery does not have an appreciable effect on the duration of labor or delivery and does not increase the risk of need for intervention in the newborn. The average effective dose is given in the following table: 1 teaspoonful (5 mL) every 4 to 6 hours, not to exceed 30 mL in 24 hours.

Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. Promethazine is used to treat several conditions, including allergies, motion sickness, nausea and vomiting, anxiety before surgery, and pain after surgery.

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